Visible-light-induced intramolecular radical cascade of α-bromo-N-benzyl-alkylamides: a new strategy to synthesize tetracyclic N‑fused indolo[2,1-a]isoquinolin-6(5H)-ones
Polycyclic indole scaffolds are ubiquitous in pharmaceuticals, natural products and materials science. Here in, we present a visible-light-initiated intramolecular aryl migration/desulfonylation/cyclization cascade reaction for the synthesis of tetracyclic indolo[2,1-a]isoquinolin-6(5H)-ones. This protocol not olny exhibited a wide substrates scope, but also provided a mild way to access a variety of tetracyclic N‑fused indoles.
- This article is part of the themed collection: Synthetic methodology in OBC