Jump to main content
Jump to site search


Visible-light-induced intramolecular radical cascade of α-bromo-N-benzyl-alkylamides: a new strategy to synthesize tetracyclic N‑fused indolo[2,1-a]isoquinolin-6(5H)-ones

Abstract

Polycyclic indole scaffolds are ubiquitous in pharmaceuticals, natural products and materials science. Here in, we present a visible-light-initiated intramolecular aryl migration/desulfonylation/cyclization cascade reaction for the synthesis of tetracyclic indolo[2,1-a]isoquinolin-6(5H)-ones. This protocol not olny exhibited a wide substrates scope, but also provided a mild way to access a variety of tetracyclic N‑fused indoles.

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Oct 2019, accepted on 03 Dec 2019 and first published on 03 Dec 2019


Article type: Paper
DOI: 10.1039/C9OB02294E
Org. Biomol. Chem., 2019, Accepted Manuscript

  •   Request permissions

    Visible-light-induced intramolecular radical cascade of α-bromo-N-benzyl-alkylamides: a new strategy to synthesize tetracyclic N‑fused indolo[2,1-a]isoquinolin-6(5H)-ones

    X. Gao, C. Li, Y. Yuan, X. Xie and Z. Zhang, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB02294E

Search articles by author

Spotlight

Advertisements