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Probing the determinants of porosity in protein frameworks: co-crystals of cytochrome c and an octa-anionic calix[4]arene

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Abstract

Sulfonato-calix[n]arenes (sclxn) are promising tools to generate crystalline protein frameworks. We report, for the first time, a lower rim functionalised octa-anionic calix[4]arene (sclx4mc) in complex with proteins. Two crystal structures of sclx4mc bound to yeast or horse heart cytochrome c (cytc) are described. Highly porous honeycomb or tubular assemblies were obtained with yeast or horse cytc, respectively. Related frameworks were obtained previously with sclx8 and sclx6 but not with sclx4, suggesting that the ligand charge is a determining factor.

Graphical abstract: Probing the determinants of porosity in protein frameworks: co-crystals of cytochrome c and an octa-anionic calix[4]arene

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Publication details

The article was received on 21 Oct 2019, accepted on 03 Dec 2019 and first published on 03 Dec 2019


Article type: Communication
DOI: 10.1039/C9OB02275A
Org. Biomol. Chem., 2020, Advance Article

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    Probing the determinants of porosity in protein frameworks: co-crystals of cytochrome c and an octa-anionic calix[4]arene

    J. M. Alex, G. Brancatelli, S. Volpi, C. Bonaccorso, A. Casnati, S. Geremia and P. B. Crowley, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02275A

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