Esterase-sensitive trithiane-based hydrogen sulfide donors

Abstract

1,3,5-Trithiane functionalized with esterase-sensitive ester groups on the methylene linkers was developed as a class of enzymatic hydrolysis-based hydrogen sulfide (H₂S) donors. The amount of H₂S released from the donors was dependent on the number of ester bonds. The donors release H₂S in a controllable manner in the presence of an enzyme.