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Issue 47, 2019
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Esterase-sensitive trithiane-based hydrogen sulfide donors

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Abstract

1,3,5-Trithiane functionalized with esterase-sensitive ester groups on the methylene linkers was developed as a class of enzymatic hydrolysis-based hydrogen sulfide (H2S) donors. The amount of H2S released from the donors was dependent on the number of ester bonds. The donors release H2S in a controllable manner in the presence of an enzyme.

Graphical abstract: Esterase-sensitive trithiane-based hydrogen sulfide donors

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Supplementary files

Article information


Submitted
20 Oct 2019
Accepted
14 Nov 2019
First published
21 Nov 2019

Org. Biomol. Chem., 2019,17, 9999-10003
Article type
Communication

Esterase-sensitive trithiane-based hydrogen sulfide donors

C. Shyaka, M. Xian and C. Park, Org. Biomol. Chem., 2019, 17, 9999
DOI: 10.1039/C9OB02273B

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