Jump to main content
Jump to site search


Thermal-mediated [1,3]-hydrogen transfer as the key step: access to oxindole–chromone hybrid collection with structural diversity

Author affiliations

Abstract

Inspired by the chemistry and biology of chromone and oxindole derivatives, herein we report the first example of thermal-mediated [1,3]-hydrogen transfer as the key step for the efficient synthesis of oxindole–chromone hybrid collections 2, which avoids additional catalyst and solvent conditions. All the oxindole–chromones 2 are smoothly obtained in >99% yields in all cases, avoiding column chromatography purification. In particular, the products 2 can act as potential synthons for further elaboration in structural diversity, which might be valuable in organic and medicinal chemistry.

Graphical abstract: Thermal-mediated [1,3]-hydrogen transfer as the key step: access to oxindole–chromone hybrid collection with structural diversity

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Oct 2019, accepted on 24 Oct 2019 and first published on 24 Oct 2019


Article type: Communication
DOI: 10.1039/C9OB02193K
Org. Biomol. Chem., 2019, Advance Article

  •   Request permissions

    Thermal-mediated [1,3]-hydrogen transfer as the key step: access to oxindole–chromone hybrid collection with structural diversity

    Y. Gong, S. Xu, X. Liu, Z. Li, X. Liu, Z. Yao and Y. Zhou, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB02193K

Search articles by author

Spotlight

Advertisements