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Cerium catalyst promoted C-S cross-coupling: Synthesis of thioethers, Dapsone and RN-18 precursors

Abstract

In this work, we present a new, efficient and green methodology for the synthesis of thioethers by C-S cross-coupling reaction by the assistance of [Ce(L-Pro)2]2Ox as a heterogeneous catalyst with good to excellent yields. The protocol was explored in scale-up, an unpublished methodology for the synthesis of a Dapsone-precursor which proved to be very effective in a short time. The catalyst [Ce(L-Pro)2]2Ox was recovered and it was shown to be effective for five more reaction cycles.

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Publication details

The article was received on 07 Oct 2019, accepted on 06 Nov 2019 and first published on 06 Nov 2019


Article type: Paper
DOI: 10.1039/C9OB02171J
Org. Biomol. Chem., 2019, Accepted Manuscript

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    Cerium catalyst promoted C-S cross-coupling: Synthesis of thioethers, Dapsone and RN-18 precursors

    J. M. D. C. Tavares Junior, C. D. G. da Silva, B. F. dos Santos, N. S. Souza, A. R. Oliveira, V. L. Kupfer, A. W. Rinaldi and N. L. D. C. Domingues, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB02171J

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