Jump to main content
Jump to site search

Issue 45, 2019
Previous Article Next Article

An efficient synthesis of benzothiazole using tetrabromomethane as a halogen bond donor catalyst

Author affiliations

Abstract

An efficient and mild protocol has been developed for the synthesis of 2-substituted benzothiazole under solvent- and metal-free conditions using CBr4 as the catalyst. This process involves the activation of a thioamide through halogen bond formation between the sulphur atom of the thioamide and bromine atom of the CBr4 molecule. The presence of halogen-bonding interaction between N-methylthioamides and tetrabromomethane has been demonstrated with several control experiments, spectroscopic analysis and density functional theory (DFT). This methodology has a wide substrate scope for the synthesis of both 2-alkyl and 2-aryl substituted benzothiazoles.

Graphical abstract: An efficient synthesis of benzothiazole using tetrabromomethane as a halogen bond donor catalyst

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Oct 2019, accepted on 29 Oct 2019 and first published on 30 Oct 2019


Article type: Paper
DOI: 10.1039/C9OB02125F
Org. Biomol. Chem., 2019,17, 9743-9756

  •   Request permissions

    An efficient synthesis of benzothiazole using tetrabromomethane as a halogen bond donor catalyst

    I. Kazi and G. Sekar, Org. Biomol. Chem., 2019, 17, 9743
    DOI: 10.1039/C9OB02125F

Search articles by author

Spotlight

Advertisements