Jump to main content
Jump to site search

Issue 45, 2019
Previous Article Next Article

Profiling the oxidative activation of DMSO-F6 by pulse radiolysis and translational potential for radical C–H trifluoromethylation

Author affiliations

Abstract

The oxidative activation of the perfluorinated analogue of dimethyl sulfoxide, DMSO-F6, by hydroxyl radicals efficiently produces trifluoromethyl radicals based on pulse radiolysis, laboratory scale experiments, and comparison of rates of reaction for analogous radical systems. In comparison to commercially available precursors, DMSO-F6 proved to be more stable, easier to handle and overall more convenient than leading F3C-reagents and may therefore be an ideal surrogate to study F3C radicals for time-resolved kinetics studies. In addition, we present an improved protocol for the preparation of this largely unexplored reagent.

Graphical abstract: Profiling the oxidative activation of DMSO-F6 by pulse radiolysis and translational potential for radical C–H trifluoromethylation

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Sep 2019, accepted on 17 Oct 2019 and first published on 17 Oct 2019


Article type: Paper
DOI: 10.1039/C9OB02119A
Org. Biomol. Chem., 2019,17, 9734-9742

  •   Request permissions

    Profiling the oxidative activation of DMSO-F6 by pulse radiolysis and translational potential for radical C–H trifluoromethylation

    N. Santschi, B. J. Jelier, S. Stähelin and T. Nauser, Org. Biomol. Chem., 2019, 17, 9734
    DOI: 10.1039/C9OB02119A

Search articles by author

Spotlight

Advertisements