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Issue 45, 2019
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Delivery of cell membrane impermeable peptides into living cells by using head-to-tail cyclized mitochondria-penetrating peptides

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Abstract

A series of cyclic Arg-rich mitochondria-penetrating peptides were prepared with variation in the macrocycle size and the chirality of Arg residues. A cyclic heptapeptide was demonstrated to be an efficient mitochondria-specific delivery vector for delivering membrane impermeable peptides.

Graphical abstract: Delivery of cell membrane impermeable peptides into living cells by using head-to-tail cyclized mitochondria-penetrating peptides

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Publication details

The article was received on 24 Sep 2019, accepted on 16 Oct 2019 and first published on 23 Oct 2019


Article type: Communication
DOI: 10.1039/C9OB02075F
Org. Biomol. Chem., 2019,17, 9693-9697

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    Delivery of cell membrane impermeable peptides into living cells by using head-to-tail cyclized mitochondria-penetrating peptides

    Q. Yang, L. Zhu, T. Xi, H. Zhu, X. Chen, M. Wu, C. Sun, C. Xu, G. Fang and X. Meng, Org. Biomol. Chem., 2019, 17, 9693
    DOI: 10.1039/C9OB02075F

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