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Cu-Catalysed oxidative amidation of cinnamic acids/arylacetic acids with 2° amines: an efficient synthesis of α-ketoamides

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Abstract

A new and convenient copper-catalysed synthesis of α-ketoamides has been accomplished using readily available cinnamic acids/arylacetic acids and 2° amines in an open atmosphere. The reaction between cinnamic acid and amine involves the formation of enamine followed by its aerobic oxidation, whereas the reaction of arylacetic acid with amine involves amide formation followed by benzylic methylene oxidation.

Graphical abstract: Cu-Catalysed oxidative amidation of cinnamic acids/arylacetic acids with 2° amines: an efficient synthesis of α-ketoamides

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Publication details

The article was received on 19 Sep 2019, accepted on 07 Oct 2019 and first published on 08 Oct 2019


Article type: Paper
DOI: 10.1039/C9OB02045D
Org. Biomol. Chem., 2019, Advance Article

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    Cu-Catalysed oxidative amidation of cinnamic acids/arylacetic acids with 2° amines: an efficient synthesis of α-ketoamides

    A. K. Sharma, A. Jaiswal and K. N. Singh, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB02045D

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