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An oxidative decarboxylative cascade cyclization of α-keto acids with 2-cyano-3-arylaniline-derived acrylamides was developed. This cascade reaction exhibits a broad substrate scope, and provides an efficient access to carbonyl-containing pyrido[4,3,2-gh]phenanthridines. A possible mechanism is proposed.

Graphical abstract: Decarboxylative cascade cyclization of α-keto acids with 2-cyano-3-arylaniline-derived acrylamides

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