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Issue 39, 2019
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Real-time monitoring of a photoactivated hydrogen persulfide donor for biological entities

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Abstract

Hydrogen persulfide (H2S2) plays an important role in sulfur-based redox signaling mechanisms. Herein, we developed a visible light activated ESIPT based H2S2 donor using a p-hydroxyphenacyl phototrigger. The unique feature of the designed H2S2 donor system is the ability to monitor the H2S2 release in real time through a non-invasive fluorescence color change approach, with the color changing from green to blue. Next, we demonstrated the detection and quantification of H2S2 using a fluorescein based “turn-on” fluorescent probe. Furthermore, in vitro studies of the designed H2S2 donor demonstrated the real-time monitored H2S2 release and cytoprotective ability in the highly oxidizing cellular environment of MDA-MB-468 cells.

Graphical abstract: Real-time monitoring of a photoactivated hydrogen persulfide donor for biological entities

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Publication details

The article was received on 10 Sep 2019, accepted on 19 Sep 2019 and first published on 19 Sep 2019


Article type: Communication
DOI: 10.1039/C9OB01982K
Org. Biomol. Chem., 2019,17, 8800-8805

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    Real-time monitoring of a photoactivated hydrogen persulfide donor for biological entities

    A. Chaudhuri, Y. Venkatesh, B. C. Jena, K. K. Behara, M. Mandal and N. D. P. Singh, Org. Biomol. Chem., 2019, 17, 8800
    DOI: 10.1039/C9OB01982K

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