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Issue 42, 2019
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Rh-Catalyzed domino synthesis of 4-hydroxy-3-methylcoumarins via branch-selective hydroacylation

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Abstract

A Rh-catalyzed domino synthesis of 4-hydroxy-3-methylcoumarins via branch-selective hydroacylation of acrylates and acrylamides using salicylaldehydes is described. This protocol under phosphine-free Rh-catalyzed conditions provided 4-hydroxy-3-methylcoumarins in high yields with excellent functional group tolerance and high selectivity.

Graphical abstract: Rh-Catalyzed domino synthesis of 4-hydroxy-3-methylcoumarins via branch-selective hydroacylation

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Publication details

The article was received on 09 Sep 2019, accepted on 08 Oct 2019 and first published on 17 Oct 2019


Article type: Communication
DOI: 10.1039/C9OB01972C
Org. Biomol. Chem., 2019,17, 9275-9279

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    Rh-Catalyzed domino synthesis of 4-hydroxy-3-methylcoumarins via branch-selective hydroacylation

    M. L. N. Rao, B. S. Ramakrishna and S. Nand, Org. Biomol. Chem., 2019, 17, 9275
    DOI: 10.1039/C9OB01972C

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