Jump to main content
Jump to site search

Issue 40, 2019
Previous Article Next Article

A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

Author affiliations

Abstract

A facile microwave assisted three-component protocol allows the synthesis of chiral aryl-1,2-mercaptoamines in water in a few minutes with high yields, bypassing the use of toxic aziridine intermediates. The chiral 1,2-mercaptoamines were then deracemized through enzymatic resolution of the racemates using monoamine oxidase (MAO-N) biocatalysts.

Graphical abstract: A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Sep 2019, accepted on 25 Sep 2019 and first published on 25 Sep 2019


Article type: Communication
DOI: 10.1039/C9OB01962F
Org. Biomol. Chem., 2019,17, 8982-8986

  •   Request permissions

    A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

    K. Lauder, D. Masci, A. Toscani, A. Al Mekdad, G. W. Black, N. L. Brown, N. J. Turner, R. Luisi and D. Castagnolo, Org. Biomol. Chem., 2019, 17, 8982
    DOI: 10.1039/C9OB01962F

Search articles by author

Spotlight

Advertisements