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Facile synthesis of N-1,2,4-oxadiazole substituted sulfoximines from N-cyano sulfoximines

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Abstract

A divergent approach has been successfully developed for the synthesis of N-1,2,4-oxadiazole substituted sulfoximines starting from N-cyano sulfoximines. This method has a wide degree of substrate scope that includes aryl, heteroaryl, alkyl, fluoroalkyl and saturated heterocyclic compounds. Excellent functional group tolerability was also observed. Extension of this methodology to nucleosides, amino acids and dipeptides was found to be successful. A gram scale reaction was also established. The major part of this method is metal free and the utility of environmentally friendly solvents such as 2-methyl THF and ionic liquids is an added advantage.

Graphical abstract: Facile synthesis of N-1,2,4-oxadiazole substituted sulfoximines from N-cyano sulfoximines

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Publication details

The article was received on 03 Sep 2019, accepted on 30 Sep 2019 and first published on 30 Sep 2019


Article type: Paper
DOI: 10.1039/C9OB01931F
Org. Biomol. Chem., 2019, Advance Article

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    Facile synthesis of N-1,2,4-oxadiazole substituted sulfoximines from N-cyano sulfoximines

    C. R. M. L., F. R. Nawaz Khan and V. Saravanan, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB01931F

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