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Transition-metal free C(sp2)–C(sp2) bond formation: arylation of 4-aminocoumarins using arynes as an aryl source

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Abstract

A mild, efficient and transition-metal free synthetic strategy has been developed for the α-arylation of 4-aminocoumarins. This synthetic strategy proceeds via C(sp2)–C(sp2) bond formation between 4-aminocoumarins and aryne precursors in a single step by simple treatment with a fluoride source in the absence of a metal-catalyst. Moreover, this methodology affords good yields of 4-amino-3-arylcoumarin derivatives bearing halide functionality.

Graphical abstract: Transition-metal free C(sp2)–C(sp2) bond formation: arylation of 4-aminocoumarins using arynes as an aryl source

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Publication details

The article was received on 02 Sep 2019, accepted on 25 Sep 2019 and first published on 25 Sep 2019


Article type: Paper
DOI: 10.1039/C9OB01919G
Org. Biomol. Chem., 2019, Advance Article

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    Transition-metal free C(sp2)–C(sp2) bond formation: arylation of 4-aminocoumarins using arynes as an aryl source

    A. Sharma and P. Gogoi, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB01919G

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