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A three-component approach to isoxazolines and isoxazoles under metal-free conditions

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Abstract

A 1,3-dipolar cycloaddition of 2-methylquinoline, tert-butyl nitrite (TBN) and alkynes or alkenes for the synthesis of biheteroaryls containing both isoxazoline/isoxazole and quinoline motifs has been developed. In this protocol, TBN serves as a convenient N–O source to convert 2-methylquinoline into intermediate nitrile oxides in situ.

Graphical abstract: A three-component approach to isoxazolines and isoxazoles under metal-free conditions

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Publication details

The article was received on 31 Aug 2019, accepted on 01 Oct 2019 and first published on 02 Oct 2019


Article type: Paper
DOI: 10.1039/C9OB01909J
Org. Biomol. Chem., 2019, Advance Article

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    A three-component approach to isoxazolines and isoxazoles under metal-free conditions

    D. Wang, F. Zhang, F. Xiao and G. Deng, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB01909J

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