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Issue 40, 2019
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Hypervalent iodane mediated reactions of N-acetyl enamines for the synthesis of oxazoles and imidazoles

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Abstract

A hypervalent iodane reagent used for the intramolecular cyclization of N-acetyl enamines and intermolecular cyclocondensation of enamines and nitriles was investigated. The reaction was performed under mild conditions and gave oxazoles and imidazoles, respectively, in moderate to excellent yields. This transformation exhibits good reactivity, selectivity and functional group tolerance. The selectivity of the intra- or intermolecular reaction is dependent on the structure of N-acetyl enamines.

Graphical abstract: Hypervalent iodane mediated reactions of N-acetyl enamines for the synthesis of oxazoles and imidazoles

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Publication details

The article was received on 29 Aug 2019, accepted on 25 Sep 2019 and first published on 25 Sep 2019


Article type: Communication
DOI: 10.1039/C9OB01895F
Org. Biomol. Chem., 2019,17, 8977-8981

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    Hypervalent iodane mediated reactions of N-acetyl enamines for the synthesis of oxazoles and imidazoles

    K. Xu, R. Yang, S. Yang, C. Jiang and Z. Ding, Org. Biomol. Chem., 2019, 17, 8977
    DOI: 10.1039/C9OB01895F

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