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Construction of indazolo[3,2-a]isoquinolines via [3 + 2] cycloaddition of benzynes

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Abstract

A [3 + 2] annulation protocol for the construction of N-substituted indazolo[3,2-a]isoquinolines starting from benzynes and C,N-cyclic azomethine imines was developed. A diverse range of highly functionalized products indazolo[3,2-a]isoquinolines featuring an indazole scaffold can be easily accessed via a one-step reaction under mild conditions, and they show good anti-proliferative activity on cancer cells.

Graphical abstract: Construction of indazolo[3,2-a]isoquinolines via [3 + 2] cycloaddition of benzynes

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Publication details

The article was received on 27 Aug 2019, accepted on 21 Sep 2019 and first published on 23 Sep 2019


Article type: Communication
DOI: 10.1039/C9OB01878F
Org. Biomol. Chem., 2019, Advance Article

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    Construction of indazolo[3,2-a]isoquinolines via [3 + 2] cycloaddition of benzynes

    Y. Li, M. Cui, F. Sha, Q. Li and X. Wu, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB01878F

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