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Issue 44, 2019
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G-quadruplexes as versatile scaffolds for catalysis

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Abstract

DNA is receiving attention as a useful biomaterial in a broad range of research fields beyond its classical role as a biopolymer for storage and delivery of genetic information. Based on its chemical and thermal stability and easy accessibility, a series of DNA-based hybrid catalysts have been developed and successfully applied to various asymmetric reactions in water. Besides the canonical Watson–Crick duplex, the G-quadruplex structure has been actively exploited as horseradish-peroxidase (HRP)-mimicking DNAzymes via specific complexation with hemin. G-quadruplexes also provide a fascinating scaffold to develop a switchable catalytic system. This review summarizes the beginning, progress, and prospects of the noncanonical DNA-based hybrid catalysts, focusing on the G-quadruplexes as versatile scaffolds for catalysis.

Graphical abstract: G-quadruplexes as versatile scaffolds for catalysis

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Article information


Submitted
27 Aug 2019
Accepted
17 Oct 2019
First published
31 Oct 2019

Org. Biomol. Chem., 2019,17, 9547-9561
Article type
Review Article

G-quadruplexes as versatile scaffolds for catalysis

J. H. Yum, S. Park and H. Sugiyama, Org. Biomol. Chem., 2019, 17, 9547
DOI: 10.1039/C9OB01876J

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