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Issue 44, 2019
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Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid

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Abstract

We report the synthesis of 4-thioferulic acid (TFA), a new ferulic acid (FA) derivative, and highlight the differences between the two compounds concerning rate and mechanism of radical scavenging activity, redox potential, acidity of the phenol/thiophenol moieties, cytotoxicity in differentiated SH-SY5Y cells, and neuroprotection against hydrogen peroxide (H2O2) and tert-butyl hydroperoxide (t-BHP) in the same cellular model.

Graphical abstract: Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid

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Publication details

The article was received on 26 Aug 2019, accepted on 23 Oct 2019 and first published on 23 Oct 2019


Article type: Paper
DOI: 10.1039/C9OB01875A
Org. Biomol. Chem., 2019,17, 9646-9654

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    Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid

    D. Chavarria, C. Fernandes, T. Silva, J. Garrido, F. Remião, P. J. Oliveira and F. Borges, Org. Biomol. Chem., 2019, 17, 9646
    DOI: 10.1039/C9OB01875A

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