Jump to main content
Jump to site search


Synthesis of 3-(tri/difluoromethyl)-1H-1,2,4-triazol-5(4H)-ones via the cyclization of hydrazinecarboxamides with tri/difluoroacetic anhydride

Author affiliations

Abstract

An efficient method for the synthesis of structurally diverse 4-aryl-3-(tri/difluoromethyl)-1H-1,2,4-triazol-5(4H)-ones through the cyclization of hydrazinecarboxamides with tri/difluoroacetic anhydride is presented. The method is simple and environmentally benign, providing tri/difluoromethylated 1,2,4-triazol-5(4H)-ones in moderate-to-good yields. A mechanism is proposed to proceed via a tandem reaction of tri/difluoroacetylation, nucleophilic addition and water elimination. Some of these compounds exhibit promising insecticidal activities.

Graphical abstract: Synthesis of 3-(tri/difluoromethyl)-1H-1,2,4-triazol-5(4H)-ones via the cyclization of hydrazinecarboxamides with tri/difluoroacetic anhydride

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Aug 2019, accepted on 30 Sep 2019 and first published on 08 Oct 2019


Article type: Paper
DOI: 10.1039/C9OB01865D
Org. Biomol. Chem., 2019, Advance Article

  •   Request permissions

    Synthesis of 3-(tri/difluoromethyl)-1H-1,2,4-triazol-5(4H)-ones via the cyclization of hydrazinecarboxamides with tri/difluoroacetic anhydride

    Y. You, Y. Chen, C. You, J. Wang and Z. Weng, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB01865D

Search articles by author

Spotlight

Advertisements