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Functionalization of activated methylene C–H bonds with nitroarenes and sulfur for the synthesis of thioamides

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Abstract

We report a method to obtain arylthioamides by the functionalization of sp3 C–H bonds in phenylacetic acids and benzyl alcohols. Reactions proceeded without the use of any solvents and were compatible with many functionalities and heterocycles. These conditions allow for a rapid synthesis of thioamides from simple, commercial substrates.

Graphical abstract: Functionalization of activated methylene C–H bonds with nitroarenes and sulfur for the synthesis of thioamides

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Publication details

The article was received on 08 Aug 2019, accepted on 27 Sep 2019 and first published on 04 Oct 2019


Article type: Communication
DOI: 10.1039/C9OB01751H
Org. Biomol. Chem., 2019, Advance Article

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    Functionalization of activated methylene C–H bonds with nitroarenes and sulfur for the synthesis of thioamides

    N. T. Do, K. M. Tran, H. T. Phan, T. A. To, T. T. Nguyen and N. T. S. Phan, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB01751H

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