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Synthesis of fused imidazo[1,2-a]pyridines derivatives through cascade C(sp2)–H functionalizations

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Abstract

An efficient and convenient synthesis of diversely substituted naphtho[1′,2′:4,5]imidazo[1,2-a]-pyridine derivatives from the cascade reactions of 2-arylimidazo[1,2-a]pyridines with a-diazo carbonyl compounds via Rh(III)-catalyzed regioselective C(sp2)–H alkylation followed by intramolecular annulation is presented. Interestingly, when simple 2-arylimidazo[1,2-a]pyridines were used as the substrates, 5,6-disubstituted naphtho[1′,2′:4,5]imidazo[1,2-a]pyridines were efficiently obtained, whereas using 2-arylimidazo[1,2-a]pyridine-3-carbaldehydes as the substrates afforded naphtho[1′,2′:4,5]imidazo[1,2-a]-pyridine-5-carboxylates as the dominating products. Compared with literature methods for the synthesis of naphtho[1′,2′:4,5]imidazo[1,2-a]pyridine derivatives, the protocol presented herein has advantages such as easily obtainable substrates, simple operational procedure, high efficiency and excellent regio- and chemoselectivity.

Graphical abstract: Synthesis of fused imidazo[1,2-a]pyridines derivatives through cascade C(sp2)–H functionalizations

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Publication details

The article was received on 07 Aug 2019, accepted on 30 Sep 2019 and first published on 01 Oct 2019


Article type: Paper
DOI: 10.1039/C9OB01744E
Org. Biomol. Chem., 2019, Advance Article

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    Synthesis of fused imidazo[1,2-a]pyridines derivatives through cascade C(sp2)–H functionalizations

    B. Li, N. Shen, X. Zhang and X. Fan, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB01744E

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