Issue 32, 2019

An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange

Abstract

The fluorinase enzyme from Streptomyces cattleya is shown to catalyse a direct displacement of bromide and iodide by fluoride ion from 5′-bromodeoxyadenosine (5′-BrDA) and 5′-iododeoxyadenosine (5′-IDA) respectively to form 5′-fluorodeoxyadenosine (5′-FDA) in the absence of L-methionine (L-Met) or S-adenosyl-L-methionine (SAM). 5′-BrDA is the most efficient substrate for this enzyme catalysed Finkelstein reaction.

Graphical abstract: An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange

Supplementary files

Article information

Article type
Paper
Submitted
27 Jun 2019
Accepted
25 Jul 2019
First published
25 Jul 2019

Org. Biomol. Chem., 2019,17, 7493-7496

An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange

P. T. Lowe, S. L. Cobb and D. O'Hagan, Org. Biomol. Chem., 2019, 17, 7493 DOI: 10.1039/C9OB01625B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements