Triflic acid-mediated synthesis of thioglycosides†
Abstract
An efficient synthesis of thioglycosides from per-acetates in the presence of triflic acid is described. The developed protocol features high reaction rates and product yields. Some reactive sugar series give high efficiency in the presence of sub-stoichiometric trifluoromethanesulfonic acid (TfOH) in contrast to other known protocols that require multiple equivalents of Lewis acids to reach high conversion rates.
- This article is part of the themed collections: Chemical Biology in OBC and Synthetic methodology in OBC