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Issue 36, 2019
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Triflic acid-mediated synthesis of thioglycosides

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An efficient synthesis of thioglycosides from per-acetates in the presence of triflic acid is described. The developed protocol features high reaction rates and product yields. Some reactive sugar series give high efficiency in the presence of sub-stoichiometric trifluoromethanesulfonic acid (TfOH) in contrast to other known protocols that require multiple equivalents of Lewis acids to reach high conversion rates.

Graphical abstract: Triflic acid-mediated synthesis of thioglycosides

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The article was received on 20 Jul 2019, accepted on 27 Aug 2019 and first published on 28 Aug 2019

Article type: Communication
DOI: 10.1039/C9OB01610D
Org. Biomol. Chem., 2019,17, 8379-8383

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    Triflic acid-mediated synthesis of thioglycosides

    S. Escopy, Y. Singh and A. V. Demchenko, Org. Biomol. Chem., 2019, 17, 8379
    DOI: 10.1039/C9OB01610D

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