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Issue 41, 2019
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Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules

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Abstract

The Stille coupling between organostannanes and organohalides is an effective catalytic method for organic synthesis. Despite the ample amount of published results in this area, finding the optimal conditions for this transformation is often not straightforward. It was observed that this reaction could be accelerated with improved efficiency by the addition of a Cu(I) salt and fluoride. This review summarises the application of this simple protocol in the synthesis of natural products, their analogues and other biologically active molecules, from 2004 to 2018.

Graphical abstract: Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules

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Publication details

The article was received on 19 Jul 2019, accepted on 18 Sep 2019 and first published on 20 Sep 2019


Article type: Review Article
DOI: 10.1039/C9OB01602C
Org. Biomol. Chem., 2019,17, 9095-9123

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    Application of copper(I) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules

    V. Lee, Org. Biomol. Chem., 2019, 17, 9095
    DOI: 10.1039/C9OB01602C

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