Issue 41, 2019

Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules

Abstract

The Stille coupling between organostannanes and organohalides is an effective catalytic method for organic synthesis. Despite the ample amount of published results in this area, finding the optimal conditions for this transformation is often not straightforward. It was observed that this reaction could be accelerated with improved efficiency by the addition of a Cu(I) salt and fluoride. This review summarises the application of this simple protocol in the synthesis of natural products, their analogues and other biologically active molecules, from 2004 to 2018.

Graphical abstract: Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules

Article information

Article type
Review Article
Submitted
19 Jul 2019
Accepted
18 Sep 2019
First published
20 Sep 2019

Org. Biomol. Chem., 2019,17, 9095-9123

Application of copper(I) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules

V. Lee, Org. Biomol. Chem., 2019, 17, 9095 DOI: 10.1039/C9OB01602C

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