Jump to main content
Jump to site search


Direct Methyl C(sp3)−H Bonds Azolation of Thioanisoles via Oxidative Radical Coupling

Abstract

A method for metal-free, 1,3-dibromo-5,5-dimethylhydantoin mediated methyl C(sp3)−H bond azolation of thioanisoles has been developed, affording a facile route for the construction of nitrogen-functionalized thioanisoles, possibly via a nitrogen-centered radical process. This reaction represents an important addition to the limited number of existing methods for the methyl C(sp3)−H bond functionalization of thioanisoles, and would find practical application in the synthesis of nitrogen-alkylated azoles.

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Jul 2019, accepted on 15 Aug 2019 and first published on 15 Aug 2019


Article type: Communication
DOI: 10.1039/C9OB01530B
Org. Biomol. Chem., 2019, Accepted Manuscript

  •   Request permissions

    Direct Methyl C(sp3)−H Bonds Azolation of Thioanisoles via Oxidative Radical Coupling

    X. Wang, C. Li, Y. Zhang, B. Zhang and K. Sun, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB01530B

Search articles by author

Spotlight

Advertisements