Jump to main content
Jump to site search


Organocatalytic asymmetric spirocyclization reactions of cyclic 2,4-dienones with cyanoketones: synthesis of spiro-dihydropyrano cyclohexanones

Author affiliations

Abstract

The first organocatalytic asymmetric synthesis of spiro-dihydropyrano cyclohexanones has been developed via the cascade reaction between cyanoketones and cyclic 2,4-dienones. A cinchona alkaloid-derived bifunctional primary amine catalyst in combination with N-Boc-tleucine was found to be the most effective for this spirocyclization reaction and provided the desired products in moderate to good yields with high enantioselectivities.

Graphical abstract: Organocatalytic asymmetric spirocyclization reactions of cyclic 2,4-dienones with cyanoketones: synthesis of spiro-dihydropyrano cyclohexanones

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Jun 2019, accepted on 31 Jul 2019 and first published on 01 Aug 2019


Article type: Communication
DOI: 10.1039/C9OB01415B
Org. Biomol. Chem., 2019, Advance Article

  •   Request permissions

    Organocatalytic asymmetric spirocyclization reactions of cyclic 2,4-dienones with cyanoketones: synthesis of spiro-dihydropyrano cyclohexanones

    B. Mondal, M. Balha and S. C. Pan, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB01415B

Search articles by author

Spotlight

Advertisements