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Issue 29, 2019
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A novel chemiluminescent probe for hydrazine detection in water and HeLa cells

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Abstract

Hydrazine is a substance harmful to humans and the environment, necessitating the development of a sensitive and specific detection method. Herein, a novel chemiluminescent probe based on Schaap's adamantylidene–dioxetane (CL-HZ) for detecting hydrazine was synthesized and evaluated. The probe was activated by the removal of a protecting group to form free phenoxy-dioxetane, when treated with hydrazine. It then showed a noticeable and sustainable fluorescent response without excitation, with intensity increasing 51-fold in the presence of hydrazine. CL-HZ can be used in 96-well high-throughput assays for analysis of hydrazine in polluted water samples and was successfully applied for the detection of hydrazine in living cells.

Graphical abstract: A novel chemiluminescent probe for hydrazine detection in water and HeLa cells

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Publication details

The article was received on 22 Jun 2019, accepted on 09 Jul 2019 and first published on 10 Jul 2019


Article type: Communication
DOI: 10.1039/C9OB01407A
Org. Biomol. Chem., 2019,17, 6975-6979

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    A novel chemiluminescent probe for hydrazine detection in water and HeLa cells

    J. Liu, J. Jiang, Y. Dou, F. Zhang, X. Liu, J. Qu and Q. Zhu, Org. Biomol. Chem., 2019, 17, 6975
    DOI: 10.1039/C9OB01407A

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