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BPO-promoted direct oxidative C–H functionalization of unactivated alkanes into 6-alkyl-6H-benzo[c]chromenes under transition-metal-free conditions

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Abstract

A simple and efficient BPO-promoted free radical-based cascade reaction of biaryl vinyl ethers with easily available unactivated alkanes has been developed. A series of 6-alkyl-6H-benzo[c]chromenes have been successfully obtained in moderate to high yields under transition-metal-free conditions. This method can also be utilized to synthesize 6-alkyl-6H-benzo[c]thiochromenes from the corresponding biaryl vinyl thioethers.

Graphical abstract: BPO-promoted direct oxidative C–H functionalization of unactivated alkanes into 6-alkyl-6H-benzo[c]chromenes under transition-metal-free conditions

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Publication details

The article was received on 20 Jun 2019, accepted on 02 Aug 2019 and first published on 05 Aug 2019


Article type: Paper
DOI: 10.1039/C9OB01396B
Org. Biomol. Chem., 2019, Advance Article

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    BPO-promoted direct oxidative C–H functionalization of unactivated alkanes into 6-alkyl-6H-benzo[c]chromenes under transition-metal-free conditions

    L. Ji, Q. Deng, P. Liu and P. Sun, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB01396B

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