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Issue 32, 2019
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An efficient tandem synthesis of chromones from o-bromoaryl ynones and benzaldehyde oxime

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Abstract

An effective transition-metal-free strategy was developed for the preparation of chromones from o-bromoaryl ynones and benzaldehyde oxime through sequential C–O bond formation. This cyclization reaction could well tolerate a wide range of functional groups, and the corresponding chromones were given in moderate to excellent yields. Mechanistically, benzaldehyde oxime as a hydroxide source and 1,3-diketone derivatives as reaction intermediates were involved in this transformation.

Graphical abstract: An efficient tandem synthesis of chromones from o-bromoaryl ynones and benzaldehyde oxime

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Article information


Submitted
19 Jun 2019
Accepted
20 Jul 2019
First published
22 Jul 2019

Org. Biomol. Chem., 2019,17, 7461-7467
Article type
Paper

An efficient tandem synthesis of chromones from o-bromoaryl ynones and benzaldehyde oxime

J. Zhang, W. Yang, L. Chen, P. Chen, Y. Wang and D. Chen, Org. Biomol. Chem., 2019, 17, 7461
DOI: 10.1039/C9OB01387C

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