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Issue 29, 2019
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Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs

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Abstract

We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chemical reactions.

Graphical abstract: Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs

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Publication details

The article was received on 19 Jun 2019, accepted on 03 Jul 2019 and first published on 10 Jul 2019


Article type: Communication
DOI: 10.1039/C9OB01384A
Org. Biomol. Chem., 2019,17, 6970-6974

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    Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs

    R. Walther, M. T. Jarlstad Olesen and A. N. Zelikin, Org. Biomol. Chem., 2019, 17, 6970
    DOI: 10.1039/C9OB01384A

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