Issue 29, 2019

Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs

Abstract

We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chemical reactions.

Graphical abstract: Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs

Supplementary files

Article information

Article type
Communication
Submitted
19 Jun 2019
Accepted
03 Jul 2019
First published
10 Jul 2019

Org. Biomol. Chem., 2019,17, 6970-6974

Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs

R. Walther, M. T. Jarlstad Olesen and A. N. Zelikin, Org. Biomol. Chem., 2019, 17, 6970 DOI: 10.1039/C9OB01384A

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