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Abstract | Cited by

We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chemical reactions.

Graphical abstract: Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs

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