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Issue 31, 2019
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Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide

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Abstract

Disialosyl globopentaosylceramide (DSGb5) is often expressed by renal cell carcinomas. To investigate properties of DSGb5, we have prepared its oligosaccharide moiety by chemically synthesizing Gb5 which was enzymatically sialylated using the mammalian sialyltransferases ST3Gal1 and ST6GalNAc5. Glycan microarray binding studies indicate that Siglec-7 does not recognize DSGb5, and preferentially binds Neu5Acα(2,8)Neu5Ac containing glycans.

Graphical abstract: Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide

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Publication details

The article was received on 17 Jun 2019, accepted on 18 Jul 2019 and first published on 18 Jul 2019


Article type: Communication
DOI: 10.1039/C9OB01368G
Org. Biomol. Chem., 2019,17, 7304-7308

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    Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide

    I. M. E. 't Hart, T. Li, M. A. Wolfert, S. Wang, K. W. Moremen and G. Boons, Org. Biomol. Chem., 2019, 17, 7304
    DOI: 10.1039/C9OB01368G

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