Issue 37, 2019

Gold(i)-catalyzed Nicholas reaction with aromatic molecules utilizing a bifunctional propargyl dicobalt hexacarbonyl complex

Abstract

A benchtop-stable reagent for the catalytic Nicholas reaction was developed. By combining a propargyl dicobalt hexacarbonyl cluster with an ortho-alkynylbenzoate unit and a fluorous tag, introduction of a propargyl hexacarbonyl complex on various aromatic compounds having acid- or base-sensitive functional groups becomes possible by using a gold(I) catalyst. In addition, the presence of a fluorous tag facilitates convenient separation of the target products from byproducts.

Graphical abstract: Gold(i)-catalyzed Nicholas reaction with aromatic molecules utilizing a bifunctional propargyl dicobalt hexacarbonyl complex

Supplementary files

Article information

Article type
Communication
Submitted
14 Jun 2019
Accepted
15 Jul 2019
First published
17 Jul 2019

Org. Biomol. Chem., 2019,17, 8522-8526

Gold(I)-catalyzed Nicholas reaction with aromatic molecules utilizing a bifunctional propargyl dicobalt hexacarbonyl complex

T. Okamura, S. Fujiki, Y. Iwabuchi and N. Kanoh, Org. Biomol. Chem., 2019, 17, 8522 DOI: 10.1039/C9OB01348B

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