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Issue 33, 2019
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Formation of i-motifs from acyclic (L)-threoninol nucleic acids

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Acyclic (L)-threoninol nucleic acids ((L)-aTNA) containing poly-cytosines are prepared and investigated at various pH values, revealing the formation of a highly stable structure at lower pH that have the characteristics of an i-motif. Depending on the sequence, the aTNA forms inter-, bi- and intra-molecular i-motif structures. Pyrene was conjugated to aTNA sequences and both monomeric and excimer fluorescence were efficiently quenched by the i-motif structures and thus demonstrated that the aTNA i-motif can serve as a pH switch.

Graphical abstract: Formation of i-motifs from acyclic (l)-threoninol nucleic acids

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The article was received on 26 May 2019, accepted on 06 Jul 2019 and first published on 19 Jul 2019

Article type: Communication
DOI: 10.1039/C9OB01220F
Org. Biomol. Chem., 2019,17, 7655-7659

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    Formation of i-motifs from acyclic (L)-threoninol nucleic acids

    V. Kumar, T. J. D. Nguyen, J. Palmfeldt and K. V. Gothelf, Org. Biomol. Chem., 2019, 17, 7655
    DOI: 10.1039/C9OB01220F

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