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Issue 35, 2019
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Total synthesis of wikstrol A and wikstrol B

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Abstract

The first total synthesis of wikstrol A and wikstrol B was achieved by employing aldol reaction, Sharpless asymmetric dihydroxylation, regioselective iodination, Sonogashira coupling, and rhodium-catalyzed oxidative coupling as key steps. The structure of the key intermediate for wikstrol A was confirmed via its derivative by single-crystal X-ray analysis.

Graphical abstract: Total synthesis of wikstrol A and wikstrol B

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Publication details

The article was received on 26 May 2019, accepted on 06 Aug 2019 and first published on 07 Aug 2019


Article type: Paper
DOI: 10.1039/C9OB01219B
Org. Biomol. Chem., 2019,17, 8206-8213

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    Total synthesis of wikstrol A and wikstrol B

    K. Lu, M. Li, Y. Huang, Y. Sun, Z. Gong, Q. Wei, X. Zhao, Y. Zhang and P. Yu, Org. Biomol. Chem., 2019, 17, 8206
    DOI: 10.1039/C9OB01219B

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