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Issue 28, 2019
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Supramolecular assembly of functional peptide–polymer conjugates

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Abstract

The following review gives an overview about synthetic peptide–polymer conjugates as macromolecular building blocks and their self-assembly into a variety of supramolecular architectures, from supramolecular polymer chains, to anisotropic 1D arrays, 2D layers, and more complex 3D networks. A selection of recent literature examples using linear, coiled-coil and cyclic peptide motifs is provided. The reversible nature of the unimer-to-supramolecular polymer transition provides unique opportunities to investigate mechanistic aspects of the supramolecular assembly, with respect to the thermodynamic or kinetic parameters and furthermore provides exciting opportunities for non-equilibrium assembly strategies. Using specific examples we also highlight some of the biological or mechanical function that arises from this versatile class of supramolecular biomaterials.

Graphical abstract: Supramolecular assembly of functional peptide–polymer conjugates

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Publication details

The article was received on 21 May 2019, accepted on 19 Jun 2019 and first published on 20 Jun 2019


Article type: Review Article
DOI: 10.1039/C9OB01191A
Org. Biomol. Chem., 2019,17, 6719-6734

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    Supramolecular assembly of functional peptide–polymer conjugates

    R. Otter and P. Besenius, Org. Biomol. Chem., 2019, 17, 6719
    DOI: 10.1039/C9OB01191A

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