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Issue 28, 2019
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Supramolecular assembly of functional peptide–polymer conjugates

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Abstract

The following review gives an overview about synthetic peptide–polymer conjugates as macromolecular building blocks and their self-assembly into a variety of supramolecular architectures, from supramolecular polymer chains, to anisotropic 1D arrays, 2D layers, and more complex 3D networks. A selection of recent literature examples using linear, coiled-coil and cyclic peptide motifs is provided. The reversible nature of the unimer-to-supramolecular polymer transition provides unique opportunities to investigate mechanistic aspects of the supramolecular assembly, with respect to the thermodynamic or kinetic parameters and furthermore provides exciting opportunities for non-equilibrium assembly strategies. Using specific examples we also highlight some of the biological or mechanical function that arises from this versatile class of supramolecular biomaterials.

Graphical abstract: Supramolecular assembly of functional peptide–polymer conjugates

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Article information


Submitted
21 May 2019
Accepted
19 Jun 2019
First published
20 Jun 2019

Org. Biomol. Chem., 2019,17, 6719-6734
Article type
Review Article

Supramolecular assembly of functional peptide–polymer conjugates

R. Otter and P. Besenius, Org. Biomol. Chem., 2019, 17, 6719
DOI: 10.1039/C9OB01191A

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