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Issue 23, 2019
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Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy

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Abstract

A new robust strategy was reported for the epimerization-free synthesis of C-terminal Cys-containing peptide acids through mercaptoethanol-mediated hydrolysis of peptide thioesters prepared in situ from peptide hydrazides. This simple-to-operate and highly efficient method avoids the use of derivatization reagents for resin modification, thus providing a practical avenue for the preparation of C-terminal Cys-containing peptide acids.

Graphical abstract: Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy

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Publication details

The article was received on 14 May 2019, accepted on 15 May 2019 and first published on 17 May 2019


Article type: Communication
DOI: 10.1039/C9OB01114E
Org. Biomol. Chem., 2019,17, 5698-5702

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    Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy

    C. Zuo, B. Yan, H. Zhu, W. Shi, T. Xi, J. Shi and G. Fang, Org. Biomol. Chem., 2019, 17, 5698
    DOI: 10.1039/C9OB01114E

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