Jump to main content
Jump to site search


Robust Synthesis of C-terminal Cysteine-Containing Peptide Acids through A Peptide Hydrazide-Based Strategy

Abstract

A new robust strategy was reported for epimerization-free synthesis of C-terminal Cys-containing peptide acids through mercaptoethanol-mediated hydrolysis of peptide thioesters made in situ from peptide hydrazides. This simple-to-operate and highly efficient method avoids the use of derivatization reagents for resin modification, thus providing a practical avenue for the preparation of C-terminal Cys-containing peptide acids.

Back to tab navigation

Supplementary files

Publication details

The article was accepted on 15 May 2019 and first published on 17 May 2019


Article type: Communication
DOI: 10.1039/C9OB01114E
Org. Biomol. Chem., 2019, Accepted Manuscript

  •   Request permissions

    Robust Synthesis of C-terminal Cysteine-Containing Peptide Acids through A Peptide Hydrazide-Based Strategy

    C. Zuo, B. Yan, H. Zhu, W. Shi, T. Xi, J. Shi and G. Fang, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB01114E

Search articles by author

Spotlight

Advertisements