Issue 26, 2019

Convenient one-pot access to 2H-3-nitrothiochromenes from 2-bromobenzaldehydes, sodium sulfide and β-nitrostyrenes

Abstract

An efficient synthesis of 2H-3-nitrothiochromenes via a cascade reaction was established. Starting from commercially available o-bromobenzaldehydes and β-nitrostyrenes with sodium sulfide nonahydrate as an inexpensive sulfur source, various substituted thiochromenes were synthesized with high functional group tolerance without any added transition metal catalyst or additive.

Graphical abstract: Convenient one-pot access to 2H-3-nitrothiochromenes from 2-bromobenzaldehydes, sodium sulfide and β-nitrostyrenes

Supplementary files

Article information

Article type
Communication
Submitted
08 May 2019
Accepted
11 Jun 2019
First published
11 Jun 2019

Org. Biomol. Chem., 2019,17, 6355-6358

Convenient one-pot access to 2H-3-nitrothiochromenes from 2-bromobenzaldehydes, sodium sulfide and β-nitrostyrenes

T. T. H. Le, C. Youhei, Q. H. Le, T. B. Nguyen and D. H. Mac, Org. Biomol. Chem., 2019, 17, 6355 DOI: 10.1039/C9OB01060B

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