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Issue 23, 2019
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Importance of the main chain of lysine for histone lysine methyltransferase catalysis

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Abstract

Histone lysine methyltransferases (KMTs) are biomedicinally important class of epigenetic enzymes that catalyse methylation of lysine residues in histones and other proteins. Enzymatic and computational studies on the simplest lysine analogues that possess a modified main chain demonstrate that the lysine's backbone contributes significantly to functional KMT binding and catalysis.

Graphical abstract: Importance of the main chain of lysine for histone lysine methyltransferase catalysis

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Publication details

The article was received on 06 May 2019, accepted on 20 May 2019 and first published on 20 May 2019


Article type: Communication
DOI: 10.1039/C9OB01038F
Org. Biomol. Chem., 2019,17, 5693-5697

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    Importance of the main chain of lysine for histone lysine methyltransferase catalysis

    A. H. K. Al Temimi, R. S. Teeuwen, V. Tran, A. J. Altunc, D. C. Lenstra, W. Ren, P. Qian, H. Guo and J. Mecinović, Org. Biomol. Chem., 2019, 17, 5693
    DOI: 10.1039/C9OB01038F

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