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Structural characteristics requisite for the ligand-based selective detection of i-motif DNA

Abstract

Here, we have explored the light-up property of coumarin 343 (C343) selectively towards various i-motif DNA based on the recognition of hemi-protonated cytosine–cytosine base pairing, unlike other DNA structures. We have also demonstrated the versatile ability of this i-motif ligand, i.e., C343 towards both intermolecular and intramolecular i-motif DNA differing in the chain lengths, molecularity and sizes, which is observed in various oncogene promoters. A systematic study between i-motif DNA with various coumarin derivatives helps to understand the structural characteristics required for an ideal ligand, which can be useful for future designing of any i-motif DNA ligands.

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Supplementary files

Publication details

The article was received on 03 May 2019, accepted on 07 May 2019 and first published on 08 May 2019


Article type: Paper
DOI: 10.1039/C9OB01020C
Org. Biomol. Chem., 2019, Accepted Manuscript

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    Structural characteristics requisite for the ligand-based selective detection of i-motif DNA

    S. satpathi, S. Sappati, K. Das and P. Hazra, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB01020C

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