Jump to main content
Jump to site search

Issue 21, 2019
Previous Article Next Article

Structural characteristics requisite for the ligand-based selective detection of i-motif DNA

Author affiliations

Abstract

Here, we have explored the light-up property of coumarin 343 (C343) selectively towards various i-motif DNAs based on the recognition of hemi-protonated cytosine–cytosine base pairing, unlike other DNA structures. We have also demonstrated the versatile ability of this i-motif ligand, i.e., the affinity of C343 towards both intermolecular and intramolecular i-motif DNA differing in the chain lengths, molecularity and sizes, which is observed in various oncogene promoters. A systematic study between i-motif DNA and various coumarin derivatives helps in understanding the structural characteristics required for an ideal ligand, which can be useful for future design of any i-motif DNA ligands.

Graphical abstract: Structural characteristics requisite for the ligand-based selective detection of i-motif DNA

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 May 2019, accepted on 07 May 2019 and first published on 08 May 2019


Article type: Paper
DOI: 10.1039/C9OB01020C
Org. Biomol. Chem., 2019,17, 5392-5399

  •   Request permissions

    Structural characteristics requisite for the ligand-based selective detection of i-motif DNA

    S. Satpathi, S. Sappati, K. Das and P. Hazra, Org. Biomol. Chem., 2019, 17, 5392
    DOI: 10.1039/C9OB01020C

Search articles by author

Spotlight

Advertisements