Jump to main content
Jump to site search


Selective recognition of acetylcholine over choline by a fluorescent cage

Author affiliations

Abstract

A fluorescent hemicryptophane has been synthesized and can be used as a turn on receptor of acetylcholine. A binding constant of 2.4 × 104 M−1 was measured for this neurotransmitter, and its selective and sensitive detection over choline and choline phosphate was achieved. NMR and DFT calculations provide insight into the interactions involved in this selective recognition process.

Graphical abstract: Selective recognition of acetylcholine over choline by a fluorescent cage

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Apr 2019, accepted on 07 May 2019 and first published on 15 May 2019


Article type: Communication
DOI: 10.1039/C9OB00931K
Org. Biomol. Chem., 2019, Advance Article

  •   Request permissions

    Selective recognition of acetylcholine over choline by a fluorescent cage

    A. Long, N. Fantozzi, S. Pinet, E. Genin, R. Pétuya, D. Bégué, V. Robert, J. Dutasta, I. Gosse and A. Martinez, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB00931K

Search articles by author

Spotlight

Advertisements