Strategies towards the synthesis of anti-tuberculosis drugs
The antituberculosis drugs have captured the attention of scientific community due to the emergence of drug resistance. Hence, the development of new analogs and new drugs are required which can treat drug-resistant tuberculosis. In this report, we reviewed the strategies towards the synthesis of antituberculosis drugs. These strategies include biosynthetic and semisynthetic approaches, resolution based strategies, microbial transformations, solid phase synthesis, and asymmetric synthesis. As stereochemistry is an important hallmark of many drugs, the strategies based on asymmetric synthesis are described in detail. The emphasis on semisynthetic approaches is given for the aminoglycoside antibiotics.