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Strategies towards the synthesis of anti-tuberculosis drugs


The antituberculosis drugs have captured the attention of scientific community due to the emergence of drug resistance. Hence, the development of new analogs and new drugs are required which can treat drug-resistant tuberculosis. In this report, we reviewed the strategies towards the synthesis of antituberculosis drugs. These strategies include biosynthetic and semisynthetic approaches, resolution based strategies, microbial transformations, solid phase synthesis, and asymmetric synthesis. As stereochemistry is an important hallmark of many drugs, the strategies based on asymmetric synthesis are described in detail. The emphasis on semisynthetic approaches is given for the aminoglycoside antibiotics.

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Publication details

The article was received on 08 Mar 2019, accepted on 01 May 2019 and first published on 01 May 2019

Article type: Review Article
DOI: 10.1039/C9OB00817A
Org. Biomol. Chem., 2019, Accepted Manuscript

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    Strategies towards the synthesis of anti-tuberculosis drugs

    H. B. Rode, D. M. Lade, R. L. Gr�e, P. S. Mainkar and S. Chandrasekhar, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB00817A

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