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Strategies towards the synthesis of anti-tuberculosis drugs

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Abstract

Antituberculosis drugs have captured the attention of the scientific community due to the emergence of drug resistance. Hence, the development of new analogs and new drugs which can treat drug-resistant tuberculosis is required. In this report, we reviewed the strategies towards the synthesis of antituberculosis drugs. These strategies include semisynthetic approaches, resolution based strategies, microbial transformations, solid phase synthesis, and asymmetric synthesis. As stereochemistry is an important hallmark of many drugs, the strategies based on asymmetric synthesis are described in detail. The emphasis on semisynthetic approaches is given for aminoglycoside antibiotics.

Graphical abstract: Strategies towards the synthesis of anti-tuberculosis drugs

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Publication details

The article was received on 08 Mar 2019, accepted on 01 May 2019 and first published on 01 May 2019


Article type: Review Article
DOI: 10.1039/C9OB00817A
Org. Biomol. Chem., 2019, Advance Article

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    Strategies towards the synthesis of anti-tuberculosis drugs

    H. B. Rode, D. M. Lade, R. Grée, P. S. Mainkar and S. Chandrasekhar, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB00817A

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