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Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi

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Abstract

Polyketide synthase (PKS) gene-guided genome mining in a cricket-associated fungus, Penicillium soppi, revealed a cryptic biosynthetic gene cluster that contained a highly reducing PKS (HR-PKS), a type III PKS, and a P450 gene. Heterologous expression of the cluster in Aspergillus oryzae led to the isolation of novel alkylresorcinols with a unique Z,E,Z-triene motif. This study displays an unusual biosynthetic mechanism of an HR-PKS and a new releasing mechanism via a type III PKS in fungi.

Graphical abstract: Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi

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Publication details

The article was received on 08 Apr 2019, accepted on 01 May 2019 and first published on 01 May 2019


Article type: Communication
DOI: 10.1039/C9OB00807A
Org. Biomol. Chem., 2019, Advance Article

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    Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi

    A. Kaneko, Y. Morishita, K. Tsukada, T. Taniguchi and T. Asai, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB00807A

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