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Issue 33, 2019
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Consecutive multicomponent reactions for the synthesis of complex molecules

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Abstract

Multicomponent reactions (MCRs) involving a minimum of three reactants or reaction centers are conducted in one pot and with a single operational step. This synthetic method has a good pot, atom and step economy in the preparation of diverse and complex molecular scaffolds. Consecutive MCRs, also known as sequential or multiple MCRs, by combining two or more MCRs, exhibit even higher synthetic efficiency, product structural diversity, and molecular complexity. This review article highlights the Ugi, Groebke–Blackburn–Bienaymé, Biginelli, Huisgen, Petasis, Gewald, and Asinger reaction-initiated consecutive MCRs.

Graphical abstract: Consecutive multicomponent reactions for the synthesis of complex molecules

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Publication details

The article was received on 03 Apr 2019, accepted on 15 Jul 2019 and first published on 15 Jul 2019


Article type: Review Article
DOI: 10.1039/C9OB00772E
Org. Biomol. Chem., 2019,17, 7632-7650

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    Consecutive multicomponent reactions for the synthesis of complex molecules

    S. Zhi, X. Ma and W. Zhang, Org. Biomol. Chem., 2019, 17, 7632
    DOI: 10.1039/C9OB00772E

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